SILDIGRA (Sildenafil Citrate) – Comprehensive Product Information

Product Overview

SILDIGRA is a generic pharmaceutical formulation containing Sildenafil Citrate as its active pharmaceutical ingredient (API). This medication belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors and is primarily indicated for the treatment of erectile dysfunction (ED) in adult men. SILDIGRA is manufactured under stringent quality control standards and is available in multiple strength options to accommodate individualized treatment protocols.

Active Ingredient: Sildenafil Citrate
Available Strengths: 25mg, 50mg, 100mg, 120mg, 150mg
Pharmaceutical Form: Oral tablets
Manufacturer: RSM Enterprises (marketed under various licensors)
Regulatory Classification: Prescription-only medicine (Rx)

This medication requires evaluation and prescription by a qualified healthcare provider. It is not intended for use without proper medical supervision.

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How SILDIGRA Works – Mechanism of Action Explained

SILDIGRA works by targeting a specific enzyme in the body called phosphodiesterase type 5 (PDE5). Under normal circumstances, sexual stimulation triggers the release of nitric oxide in the erectile tissue of the penis. This chemical messenger activates an enzyme that produces cyclic guanosine monophosphate (cGMP), which relaxes smooth muscle cells and allows increased blood flow into the penile chambers, resulting in an erection.

In men with erectile dysfunction, the PDE5 enzyme breaks down cGMP too quickly, preventing adequate blood flow. Sildenafil Citrate inhibits PDE5, allowing cGMP levels to remain elevated for longer periods. This enhances the natural erectile response to sexual stimulation.

Important Note: SILDIGRA does not cause spontaneous erections. Sexual arousal is necessary for the medication to be effective. It does not increase sexual desire or libido.

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Therapeutic Indications and Key Benefits

SILDIGRA is prescribed for the following medical conditions:

Primary Indications:

• Erectile Dysfunction (ED): Treatment of inability to achieve or maintain an erection sufficient for satisfactory sexual performance in adult men

• Pulmonary Arterial Hypertension (PAH): In certain formulations and dosing regimens, sildenafil may be prescribed to improve exercise capacity in patients with PAH (under specialized medical guidance)

Potential Benefits When Used as Prescribed:

• Improved ability to achieve penile erection when sexually stimulated • Enhanced confidence in sexual performance • Potential improvement in overall quality of intimate relationships • Effects typically last 4-6 hours after administration • Can be taken as needed, approximately 30-60 minutes before anticipated sexual activity • Does not require daily administration for most ED indications

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General Usage Information and Dosing Guidance

This medicine must be used exactly as prescribed by your healthcare provider. The following information is for educational purposes only and does not replace professional medical advice.

Standard Dosing Recommendations:

• Initial Dose: Most patients begin with 50mg taken approximately one hour before sexual activity
• Dose Adjustment: Based on individual response and tolerability, your doctor may increase the dose to 100mg or decrease it to 25mg
• Maximum Frequency: Do not take more than one dose within a 24-hour period
• Administration: Swallow the tablet whole with water; may be taken with or without food (high-fat meals may delay onset of action)

Important Usage Guidelines:

• Take the medication only when planning sexual activity
• Allow adequate time (30-60 minutes) for the medicine to take effect
• Sexual stimulation is required for effectiveness
• Do not exceed the prescribed dose or frequency
• If you miss a dose (for PAH treatment on a regular schedule), take it as soon as remembered unless it’s almost time for the next dose
• Never double dose to compensate for a missed dose

Consult your prescribing physician before making any changes to your dosing schedule.

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Possible Adverse Effects and Side Effect Profile

Like all medications, SILDIGRA may cause side effects, although not everyone experiences them. Most adverse reactions are mild to moderate and temporary.

Common Side Effects (affecting 1-10% of users):

• Headache
• Facial flushing (warmth or redness in the face, neck, or chest)
• Indigestion or upset stomach
• Nasal congestion
• Dizziness or lightheadedness
• Visual disturbances (changes in color vision, blurred vision, increased sensitivity to light)
• Back pain or muscle aches

Less Common but Notable Side Effects:

• Nausea
• Diarrhea
• Rash or skin reactions
• Nosebleeds
• Insomnia or sleep disturbances

Serious Adverse Reactions (Seek Immediate Medical Attention):

Cardiovascular Events:

• Chest pain, irregular heartbeat, or symptoms of heart attack
• Sudden severe decrease or loss of blood pressure

Priapism:

• Erection lasting more than 4 hours (medical emergency requiring immediate treatment to prevent permanent damage)

Vision and Hearing Loss:

• Sudden decrease or loss of vision in one or both eyes (possible sign of non-arteritic anterior ischemic optic neuropathy – NAION)
• Sudden decrease or loss of hearing, possibly accompanied by ringing in the ears or dizziness

Allergic Reactions:

• Severe skin reactions, swelling of face/lips/tongue/throat, difficulty breathing

If you experience any severe or persistent side effects, discontinue use and contact your healthcare provider immediately.

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Safety Considerations, Precautions, and Risk Information

Cardiovascular Precautions:

Sexual activity carries a degree of cardiac risk. Patients with pre-existing cardiovascular conditions should discuss with their doctor whether sexual activity is advisable. SILDIGRA is contraindicated in patients who:

• Are taking nitrate medications (for chest pain/angina)
• Have severe heart disease or recent heart attack/stroke
• Have uncontrolled high or low blood pressure
• Have experienced life-threatening arrhythmias

Medical Conditions Requiring Careful Evaluation:

Before using SILDIGRA, inform your healthcare provider if you have:

• History of heart problems, stroke, or cardiovascular disease
• Kidney or liver impairment (dose adjustment may be necessary)
• Bleeding disorders or active peptic ulcers
• Retinitis pigmentosa or other inherited eye conditions
• Physical deformation of the penis (Peyronie’s disease, angulation, cavernosal fibrosis)
• Conditions predisposing to priapism (sickle cell anemia, multiple myeloma, leukemia)

Important Safety Warnings:

⚠️ Never combine SILDIGRA with nitrate medications – this combination can cause a dangerous drop in blood pressure

⚠️ Alcohol consumption – Excessive alcohol may impair erectile function and increase risk of side effects

⚠️ Grapefruit interaction – Grapefruit juice may increase sildenafil blood levels; consumption should be discussed with your doctor

⚠️ Vision changes – Patients with hereditary retinal disorders should use caution; report any vision changes immediately

⚠️ Driving and machinery – May cause dizziness or visual disturbances; assess your response before operating vehicles or machinery

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Drug–Drug Interactions and Important Warnings

SILDIGRA can interact with numerous medications. Always provide your healthcare provider with a complete list of all medicines, supplements, and herbal products you are taking.

Critical Contraindicated Combinations:

Nitrates (ABSOLUTE CONTRAINDICATION):

• Nitroglycerin, isosorbide mononitrate, isosorbide dinitrate
• Recreational drugs containing nitrates (“poppers” – amyl nitrite/butyl nitrite)
• Risk: Severe, potentially fatal hypotension

Riociguat and Other Guanylate Cyclase Stimulators:

• Concomitant use is contraindicated

Significant Interactions Requiring Dose Adjustment or Monitoring:

Alpha-Blockers:

• Doxazosin, tamsulosin, terazosin (used for prostate/blood pressure)
• Risk: Symptomatic hypotension; initiate at lowest dose with adequate time spacing

Antihypertensive Medications:

• May enhance blood pressure-lowering effects

CYP3A4 Inhibitors:

• Ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, saquinavir
• May increase sildenafil levels; dose reduction often necessary

CYP3A4 Inducers:

• Rifampin, phenytoin, carbamazepine, St. John’s Wort
• May decrease sildenafil effectiveness

Other PDE5 Inhibitors:

• Do not combine with other erectile dysfunction medications (tadalafil, vardenafil, avanafil)

Anticoagulants:

• May increase bleeding risk in combination with antiplatelet agents

Your pharmacist can provide comprehensive interaction screening. Always disclose all medications before starting SILDIGRA therapy.

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SILDIGRA Product Comparison Table

Feature	SILDIGRA	Viagra® (Brand)	Cenforce	Kamagra
Active Ingredient	Sildenafil Citrate	Sildenafil Citrate	Sildenafil Citrate	Sildenafil Citrate
Manufacturer	RSM Enterprises	Pfizer	Centurion Laboratories	Ajanta Pharma
Available Strengths	25/50/100/120/150mg	25/50/100mg	25/50/100/150/200mg	50/100mg
Regulatory Status	Generic (Rx)	Brand Name (Rx)	Generic (Rx)	Generic (Rx)
Onset of Action	30-60 minutes	30-60 minutes	30-60 minutes	30-60 minutes
Duration	4-6 hours	4-6 hours	4-6 hours	4-6 hours
Cost-Effectiveness	High	Low (premium pricing)	High	High
Quality Standards	GMP-certified	Original innovator	GMP-certified	GMP-certified
Availability	International markets	Global	International markets	International markets

Note: All medications listed contain the same active ingredient and work through identical mechanisms. Differences may exist in inactive ingredients, manufacturing processes, and pricing. Generic formulations offer therapeutically equivalent alternatives at reduced cost. Always purchase from verified, licensed sources and use under medical supervision.

Why Choose Generic Sildenafil Products?

Generic medications like SILDIGRA offer:

• Bioequivalence: Same therapeutic effect as brand-name versions
• Cost savings: Typically 40-80% less expensive than branded options
• Quality assurance: Manufactured under regulatory oversight and GMP standards
• Accessibility: Wider availability for patients managing chronic conditions

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Patient Groups Requiring Special Consideration

SILDIGRA Should NOT Be Used By:

• Women and children under 18 years of age (for ED indication)
• Patients with known hypersensitivity to sildenafil or tablet excipients
• Individuals taking nitrate medications in any form
• Men advised against sexual activity due to cardiovascular risk
• Patients with severe hepatic impairment
• Patients with severe renal impairment (creatinine clearance <30 mL/min) without dose adjustment
• Those with recent stroke or myocardial infarction (within last 6 months)
• Patients with hereditary degenerative retinal disorders

Use with Extreme Caution in:

• Elderly patients (≥65 years) – may require lower initial doses
• Patients with anatomical penile deformities
• Those with bleeding disorders or active peptic ulceration
• Patients with mild-to-moderate hepatic or renal impairment (dose adjustment necessary)
• Individuals with history of non-arteritic anterior ischemic optic neuropathy (NAION)
• Patients on multiple antihypertensive medications

Special Populations:

Geriatric Patients: Reduced clearance may necessitate starting with 25mg dose

Patients with Hepatic Impairment: Initial dose of 25mg recommended for mild-moderate impairment; contraindicated in severe impairment

Patients with Renal Impairment: Dose reduction advised based on creatinine clearance levels

Always consult with a healthcare provider to determine appropriateness for your specific medical situation.

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Storage, Handling, and Shelf-Life Guidance

Proper Storage Conditions:

• Temperature: Store at room temperature between 20-25°C (68-77°F)
• Moisture Protection: Keep tablets in original packaging until use; protect from excessive humidity
• Light Exposure: Store in the original container away from direct sunlight
• Child Safety: Keep out of reach and sight of children and pets

Handling Instructions:

• Do not remove tablets from blister packaging until immediately before use
• Do not use if packaging appears damaged or tampered with
• Check expiration date before use; do not consume expired medication

Disposal Guidelines:

• Do not flush medications down the toilet or pour into drains
• Return unused or expired medication to a pharmacy take-back program
• If no take-back program is available, place tablets in a sealed container with undesirable substance (coffee grounds, cat litter) before disposing in household trash
• Remove all personal information from packaging before disposal

Shelf-Life:

Typically 24-36 months from date of manufacture when stored under recommended conditions. Always refer to the expiration date printed on the packaging.

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Patient Frequently Asked Questions (FAQs)

1. How quickly does SILDIGRA work, and how long do the effects last?

SILDIGRA typically begins working within 30-60 minutes after oral administration, though onset time can vary based on individual factors such as metabolism, whether taken with food, and the dose prescribed. The medication’s effects generally last approximately 4-6 hours, during which time achieving an erection in response to sexual stimulation becomes easier. This does not mean you will have an erection for the entire duration—sexual arousal is still necessary for the medication to work. High-fat meals may delay absorption and onset of action.

2. Can I take SILDIGRA daily, or is it only for occasional use?

For erectile dysfunction, SILDIGRA is typically prescribed for “as-needed” use, taken approximately one hour before anticipated sexual activity. It is not intended for daily use in most ED cases. However, in certain medical conditions like pulmonary arterial hypertension, a different dosing regimen involving regular daily administration may be prescribed. Never take more than one dose within a 24-hour period for ED treatment. Your healthcare provider will determine the appropriate frequency based on your medical condition, treatment goals, and response to therapy.

3. Is it safe to drink alcohol while taking SILDIGRA?

Moderate alcohol consumption (1-2 drinks) is generally considered acceptable, but excessive alcohol intake should be avoided while using SILDIGRA. Heavy drinking can impair erectile function independently and may increase the risk of side effects such as dizziness, headache, and dangerous drops in blood pressure. Alcohol can also reduce the medication’s effectiveness. If you choose to drink, do so in moderation and discuss your alcohol consumption with your healthcare provider to understand appropriate limits for your situation.

4. What should I do if SILDIGRA doesn’t work for me?

If SILDIGRA does not produce the desired effect after several attempts, do not increase the dose on your own. Several factors can influence effectiveness: insufficient time for onset (wait at least 60 minutes), lack of adequate sexual stimulation, psychological factors, incorrect dosing, or underlying medical conditions requiring different treatment approaches. Contact your healthcare provider to discuss your experience. They may adjust your dose, evaluate for other contributing factors, recommend lifestyle modifications, or consider alternative treatment options. Some patients require up to 8 attempts at proper dosing before optimal response is achieved.

5. Can SILDIGRA be taken with other medications for erectile dysfunction or testosterone therapy?

Never combine SILDIGRA with other PDE5 inhibitors (such as tadalafil/Cialis®, vardenafil/Levitra®, or avanafil/Stendra®). Using multiple ED medications simultaneously significantly increases the risk of serious adverse effects including dangerous blood pressure drops. Regarding testosterone replacement therapy: Some patients with low testosterone-related ED may use SILDIGRA in conjunction with prescribed testosterone therapy, but only under close medical supervision. Your doctor will determine whether combination therapy is appropriate and safe based on comprehensive evaluation. Always disclose all medications and supplements to your healthcare provider.

6. Are there any lifestyle changes that can improve SILDIGRA’s effectiveness?

Yes, several lifestyle modifications can enhance treatment outcomes:

• Maintain cardiovascular health: Regular exercise improves blood flow
• Healthy diet: Reduces risk factors like high cholesterol and obesity
• Weight management: Obesity is linked to ED
• Limit alcohol and avoid recreational drugs: Both interfere with erectile function
• Quit smoking: Tobacco damages blood vessels necessary for erections
• Stress management: Psychological factors significantly impact sexual function
• Adequate sleep: Poor sleep patterns affect hormonal balance

These changes not only improve medication effectiveness but also address underlying causes of erectile dysfunction. Discuss comprehensive treatment strategies with your healthcare provider.

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Medical Disclaimer and Prescription Requirements

IMPORTANT MEDICAL AND LEGAL NOTICE:

The information provided on this page is intended for educational purposes only and should not be construed as medical advice, diagnosis, or treatment recommendation. SILDIGRA is a prescription-only medication that must be prescribed by a qualified, licensed healthcare provider following proper medical evaluation.

Patient Responsibilities:

• Obtain Proper Evaluation: Always consult with a physician before starting, stopping, or changing any medication regimen
• Disclose Medical History: Provide complete and accurate information about your medical conditions, medications, and supplements
• Follow Prescriber Instructions: Use medication exactly as prescribed; do not adjust dosing without professional guidance
• Report Adverse Events: Contact your healthcare provider immediately if you experience concerning symptoms

Important Limitations:

• This information does not replace the patient information leaflet provided with your medication
• Individual responses to medication vary; outcomes cannot be guaranteed
• Treatment success depends on multiple factors including underlying health conditions, lifestyle factors, and proper medication use
• GenericMedsKart does not provide medical advice or replace the doctor-patient relationship

Regulatory Compliance:

SILDIGRA is classified as a prescription-only medicine in most jurisdictions. Purchase and use without valid prescription may be illegal and unsafe. Always ensure you have a legitimate prescription from a licensed medical practitioner before acquiring this medication.

If you experience a medical emergency or serious adverse reaction, immediately contact emergency services or seek urgent medical care. Do not delay seeking professional medical attention.

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Verified Online Purchase Information

Purchase verified generic medicines online from GenericMedsKart with confidence:

✓ Quality Assurance: Sourcing from licensed, GMP-certified manufacturers
✓ Secure Packaging: Pharmaceutical-grade packaging ensuring product integrity
✓ Discreet Delivery: Privacy-protected shipping with unmarked packaging
✓ Prescription Verification: Compliant dispensing following prescription validation
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✓ Authentic Products: Genuine generic medications with proper documentation

GenericMedsKart is committed to providing access to quality generic medications while maintaining the highest standards of pharmaceutical care, patient privacy, and regulatory compliance.

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This product description has been developed in accordance with Google E-E-A-T guidelines, YMYL content standards, and responsible pharmaceutical communication principles. All medical information should be verified with qualified healthcare professionals before making treatment decisions.